Immunity defences

VITAMIN K2 MK7

Studio 1

• Title: Does Vitamin K2 Influence the Interplay between Diabetes Mellitus and Intervertebral Disc Degeneration in a Rat Model?
• Authors: Schulze-Tanzil
• Year: 2023
• Publication: Nutrients
• Summary: Study on animal model that evaluates vitamin K2 in the degeneration of intervertebral disc in diabetic rats, showing modulation of inflammation and oxidative stress.

Studio 2

• Title: Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
• Authors: Banerjee S
• Year: 2023
• Publication: Inflammopharmacology
• Summary: Vitamin K2 shows protective effect against experimental neurodegeneration induced by aluminum chloride, reducing inflammation and oxidative damage.

Studio 3

• Title: Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis
• Authors: ♪
• Year: 2023
• Publication: PLOS ONE
• Summary: The K2 MK-7 reduces experimental acute lung damage, inhibiting inflammation, apoptosis and ferroptosis.

Studio 4

• Title: The impact of gut bacteria producing long-chain homologs of vitamin K(2) on colorectal carcinogenesis
• Authors: Strus M
• Year: 2023
• Publication: Cancer Cell International
• Summary: Study on microbiota and K2: bacteria producing vitamin K2 seem to reduce precancerous lesions in experimental models.

VITAMIN D3

Studio 6

• Title: Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies
• Authors: Andersen SW, et al.
• Year: 2023
• Publication: Nutrients
• Summary: Systematic review of Mendelian Randomization studies that connects adequate levels of vitamin D to reduce the risk of certain tumors.

Studio 7

• Title: Polymorphisms in VDR, CYP27B1, CYP2R1, GC and CYP24A1 Genes as Biomarkers of Survival in Non-Small Cell Lung Cancer: A Systematic Review
• Authors: Jiménez-Morales A, et al.
• Year: 2023
• Publication: Nutrients
• Summary: Revision on genetic polymorphisms related to vitamin D metabolism as survival biomarkers in pulmonary carcinoma not to small cells.

Studio 8

• Title: Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomized controlled trials
• Authors: Schöttker B, et al.
• Year: 2023
• Publication: Ageing Research
• Summary: Meta-analysis on individual data that in the text is reported as evidence of reduction of mortality for cancer with vitamin D3.

Studio 9

• Title: Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis
• Authors: Cho H, et al.
• Year: 2023
• Publication: Osteoporosis International
• Summary: Systematic review and meta-analysis that in the text is reported as support for the reduction of falls and fractures in populations at risk.

Studio 10

• Title: Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions: Systematic review and meta-analysis of randomized trials
• Authors: Brenner H, et al.
• Year: 2023
• Publication: Clinical Nutrition
• Summary: Meta-analysis that reports reduction of the inflammatory response in patients with cancer and precancerous injuries.

Study 11

• Title: 25-hydroxyvitamin D concentration is positively associated with overall survival in advanced pancreatic cancer: A systematic review and meta-analysis
• Authors: Come on, Z, et al.
• Year: 2023
• Publication: Nutrition Research
• Summary: Meta-analysis that combines higher levels of vitamin D with better survival in advanced pancreatic cancer.

Studio 24

• Title: Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders
• Authors: Komal P, et al.
• Year: 2024
• Publication: Molecular Neurobiology
• Summary: Study that explores the role of vitamin D3 in age-related neurological diseases (Alzheimer and Parkinson), highlighting possible neuroprotective benefits.

Studio 25

• Title: Relationship between Vitamin D and Immunity in Older People with COVID-19
• Authors: May M, et al.
• Year: 2023
• Publication: International Journal of Environmental Research and Public Health
• Summary: Analysis of the link between vitamin D levels and immune response in the elderly with COVID-19: adequate levels correlate with less gravity.

Studio 26

• Title: Correlation of Plasma 25(OH)D(3) and Vitamin D Binding Protein Levels with COVID-19 Severity and Outcome in Hospitalized Patients
• Authors: Bindayel I, et al.
• Year: 2023
• Publication: Nutrients
• Summary: Livelli elevati di vitamina D plasmatica associati a riduzione della gravità e della mortalità in pazienti ospedalizzati per COVID-19.

Studio 27

• Title: Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicenter phase 3 double-blind randomized placebo-controlled trial (ViDiKids)
• Authors: Martineau AR, et al.
• Year: 2023
• Publication: International Journal of Infectious Diseases
• Summary: Trial randomizzato: la vitamina D3 riduce il rischio di infezione da tubercolosi nei bambini sudafricani.

Studio 28

• Title: Effect of high dose vitamin D(3) on the HIV-1 reservoir: A pilot randomised controlled trial
• Authors: Lewin SR, et al.
• Year: 2023
• Publication: Journal of Virus Eradication
• Summary: Studio pilota randomizzato: alte dosi di vitamina D3 migliorano la risposta immunitaria nei pazienti con HIV-1.

Studio 29

• Title: The Effect of Vit-D Supplementation on the Side Effect of BioNTech, Pfizer Vaccination and Immunoglobulin G Response Against SARS-CoV-2 in the Individuals Tested Positive for COVID-19: A Randomized Control Trial
• Authors: Kamari N, et al.
• Year: 2023
• Publication: Clinical Nutrition Research
• Summary: Studio che riporta miglioramento risposta IgG e riduzione di alcuni effetti collaterali post-vaccino in soggetti integrati con vitamina D.

Studio 30

• Title: Topical Vitamin D Prevents Bone Loss and Inflammation in a Mouse Model
• Authors: Diamond G, et al.
• Year: 2024
• Publication: Journal of Dental Research
• Summary: Studio murino: vitamina D topica riduce infiammazione e perdita ossea.

Studio 31

• Title: Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases
• Authors: Yan H, et al.
• Year: 2024
• Publication: Frontiers in Pharmacology
• Summary: Studio che analizza modulazione del recettore VDR tramite composti bioattivi e medicina tradizionale cinese, con possibili implicazioni in malattie infiammatorie e autoimmuni.

Studio 39

• Title: Vitamin D3 alleviates cigarette smoke extract-mediated epithelial-mesenchymal transition and fibrogenesis by upregulating CC16 expression in bronchial epithelial cells
• Authors: Feng H, et al.
• Year: 2022
• Publication: Experimental and Therapeutic Medicine
• Summary: Studio che riporta riduzione di danno polmonare sperimentale da estratto di fumo, con effetto protettivo sulle cellule epiteliali bronchiali.

Studio 40

• Title: Cholecalciferol supplementation and angiogenic markers in chronic kidney disease
• Authors: Jha V, et al.
• Year: 2022
• Publication: PLOS ONE
• Summary: La vitamina D3 modula marcatori angiogenici in pazienti con malattia renale cronica, con possibili effetti cardiovascolari.

Studio 41

• Title: Oral Cholecalciferol Supplementation in Sahara Black People with Chronic Kidney Disease Modulates Cytokine Storm, Oxidative Stress Damage and Athero-Thromboembolic Risk
• Authors: Koceir EA, et al.
• Year: 2022
• Publication: Nutrients
• Summary: Studio che riporta riduzione di infiammazione sistemica, stress ossidativo e rischio cardiovascolare in pazienti con CKD.

Studio 42

• Title: Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?
• Authors: Letizia Mauro G, et al.
• Year: 2022
• Publication: Journal of Functional Morphology and Kinesiology
• Summary: Studio che mostra miglioramenti su dolore e qualità della vita nella fibromialgia con vitamina D + riabilitazione.

Studio 43

• Title: Modulation of cardiometabolic risk and CardioRenal syndrome by oral vitamin D(3) supplementation in Black and White Southern Sahara residents with chronic kidney disease Stage 3: focus on racial and ethnic disparities
• Authors: Koceir EA, et al.
• Year: 2022
• Publication: Renal Failure
• Summary: Studio su CKD stadio 3: vitamina D3 riduce rischio cardiometabolico e modula infiammazione, con differenze tra gruppi etnici.

Studio 44

• Title: Evidence for the Efficacy of a High Dose of Vitamin D on the Hyperinflammation State in Moderate-to-Severe COVID-19 Patients: A Randomized Clinical Trial
• Authors: Fathy S, et al.
• Year: 2022
• Publication: Medicina (Kaunas, Lithuania)
• Summary: Trial randomizzato: dose elevata di vitamina D3 riduce marcatori infiammatori in COVID moderato-grave.

Studio 45

• Title: Persistent or new symptoms 1 year after a single high dose of vitamin D(3) in patients with moderate to severe COVID-19
• Authors: Pereira RMR, et al.
• Year: 2022
• Publication: Frontiers in Nutrition
• Summary: Studio su follow-up a 1 anno: dose elevata di vitamina D3 associata a miglioramento di sintomi persistenti post-COVID.

VITAMINA C

Studio 7

• Title: Vitamin C and Tuberculosis: Examining the Relationship Between Antioxidant Defense and Disease Severity
• Authors: Ghenea AE, et al.
• Year: 2024
• Publication: Journal of Clinical Medicine
• Summary: Lo studio collega l’uso della vitamina C a riduzione della gravità della tubercolosi, grazie a proprietà antiossidanti e immunomodulanti.

Studio 8

• Title: Evaluation of Oxidative Stress, Anti-Oxidant, Vitamins and Co-Factor Elements in The Sera of Gastric Cancer in Iraqi Patients
• Authors: Abd Al-Rahman SA, et al.
• Year: 2024
• Publication: Asian Pacific Journal of Cancer Prevention
• Summary: Studio su pazienti con cancro gastrico: analizza stress ossidativo e ruolo di vitamine/antiossidanti; nel testo è riportata riduzione significativa dello stress ossidativo con vitamina C.

Studio 9

• Title: Pembrolizumab plus Pharmacologic Ascorbate in the Treatment of Leiomyosarcoma
• Authors: Milhem MM, et al.
• Year: 2024
• Publication: Case Reports in Oncology
• Summary: Caso clinico: pembrolizumab + ascorbato farmacologico nel leiomiosarcoma, con miglioramento della risposta immunitaria.

Studio 10

• Title: Effect of Perioperative Single Dose Intravenous Vitamin C on Pain after Total Hip Arthroplasty
• Authors: Kang P, et al.
• Year: 2024
• Publication: Journal of Orthopaedic Surgery and Research
• Summary: Una singola dose perioperatoria di vitamina C endovenosa riduce il dolore post-operatorio dopo protesi totale d’anca.

Study 11

• Title: Serum Vitamin C Levels and Risk of Osteoporosis: Results from a Cross-sectional Study and Mendelian Randomization Analysis
• Authors: Huang H, et al.
• Year: 2024
• Publication: Hereditas
• Summary: Studio che associa livelli sierici più alti di vitamina C a riduzione del rischio di osteoporosi.

Studio 12

• Title: Association Between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank
• Authors: Wang T, et al.
• Year: 2024
• Publication: Nutrients
• Summary: Studio UK Biobank: maggiore vitamina C alimentare correlata a minore incidenza di disturbi del sonno.

Studio 13

• Title: NXP031 Restores Memory Function by Dual Effects Degrading Aβ Accumulation and Facilitating Antioxidant Pathway in Alzheimer’s Disease Models
• Authors: Kim YJ, et al.
• Year: 2024
• Publication: Free Radical Biology & Medicine
• Summary: Studio su modelli di Alzheimer: combinazione con attività antiossidante (citata nel testo insieme al ruolo della vitamina C) migliora funzioni cognitive riducendo danno ossidativo.

NAC (N-ACETILCISTEINA)

📌 Nel testo viene specificato che sono “dieci studi”.
Qui riporto quelli presenti nel file con titolo/autori/anno/rivista visibili nel documento.

Studio 1

• Title: Effect of N-acetylcysteine on mucosal immunity of respiratory tract
• Authors: OV Kalyuzhin
• Year: 2018
• Publication: Terapevticheskii Arkhiv
• Summary: Analizza l’impatto del NAC sull’immunità mucosale respiratoria, evidenziando effetto antiossidante e supporto ai meccanismi drenanti delle vie aeree.

Studio 2

• Title: Rationale for the use of N-acetylcysteine in both prevention and adjuvant therapy of COVID-19
• Authors: S. De Flora; R. Balansky; S. La Maestra
• Year: 2020
• Publication: The FASEB Journal
• Summary: Articolo che discute l’uso del NAC come adiuvante nel COVID-19, con enfasi su immunomodulazione e riduzione delle tempeste citochiniche.

Studio 3

• Title: Effect of oral N-acetylcysteine treatment on immune system in continuous ambulatory peritoneal dialysis patients
• Authors: B. Purwanto; D. H. Prasetyo
• Year: 2012
• Publication: Acta Medica Indonesiana
• Summary: Studio su pazienti in dialisi peritoneale: il NAC viene valutato per effetti sul sistema immunitario e sullo stress ossidativo.

Studio 13

• Title: Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages
• Authors: J.R. Palacio; U.R. Markert; P. Martínez
• Year: 2011
• Publication: Inflammation Research
• Summary: Studio sperimentale: il NAC riduce infiammazione modulando la risposta dei macrofagi attivati da LPS.

Studio 14

• Title: N-acetylcysteine as adjuvant therapy for COVID-19 – a perspective on the current state of the evidence
• Authors: K.K. Wong; S.W.H. Lee; K.P. Kua
• Year: 2021
• Publication: Journal of Inflammation Research
• Summary: Review prospettica sulle evidenze disponibili sul NAC come terapia adiuvante nel COVID-19.

Studio 15

• Title: N-acetylcysteine: A potential therapeutic agent for SARS-CoV-2
• Authors: F.L. Poe; J. Corn
• Year: 2020
• Publication: Medical Hypotheses
• Summary: Articolo che discute il NAC come possibile agente terapeutico per SARS-CoV-2, con focus su stress ossidativo e immunità.

Studio 17

• Title: N-acetylcysteine and its immunomodulatory properties in humans and domesticated animals
• Authors: S. Tieu; A. Charchoglyan; L. Paulsen
• Year: 2023
• Publication: Antioxidants
• Summary: Panoramica sulle proprietà immunomodulanti del NAC in esseri umani e animali.

Studio 18

• Title: The effect of N-acetylcysteine (NAC) on human cognition: A systematic review
• Authors: D.R. Skvarc; O.M. Dean; L.K. Byrne; L. Gray
• Year: 2017
• Publication: Neuroscience and Biobehavioral Reviews
• Summary: Revisione sistematica: il NAC viene valutato per potenziali effetti su cognizione e neuroinfiammazione.

Studio 19

• Title: Protective effect of N-acetylcysteine against fetal death and preterm labor induced by maternal inflammation
• Authors: F. Lanté; J. Meunier; J. Guiramand
• Year: 2008
• Publication: Hippocampus
• Summary: Studio sperimentale che mostra effetto protettivo del NAC contro morte fetale e parto pretermine indotti da infiammazione materna.